By a practising Australian GP
If you are over 30, there is a one in three chance you have high blood pressure. Many people feel completely well while their blood pressure quietly damages the heart, brain, kidneys and eyes. In my clinic, I regularly see patients who want to take control but struggle with current tablets. The most common complaint? A dry, irritating cough caused by older blood pressure medicines called ACE inhibitors, such as perindopril, ramipril or enalapril. Some patients feel so miserable they stop treatment altogether, putting themselves at risk of heart attack and stroke.
There is a modern, well-researched alternative: telmisartan. This article explains why telmisartan is a first-choice option for many Australians over 30, especially if you have had a cough, worry about kidney or liver health, have diabetes risk, or use salt substitutes.
Telmisartan belongs to a class called angiotensin II receptor blockers (ARBs). It blocks the hormone angiotensin II, which normally narrows blood vessels and raises blood pressure. By blocking this hormone at the receptor, telmisartan allows blood vessels to relax and widen, lowering blood pressure smoothly.
Unlike ACE inhibitors, telmisartan does not increase bradykinin, a substance that can trigger the infamous dry cough. This is why telmisartan is so well tolerated.
| Feature | ACE inhibitors (e.g. perindopril, ramipril) | Telmisartan |
|---|---|---|
| Dry cough | Common (up to 20% of patients) | Rare, similar to placebo |
| Angioedema (swelling of face/airway) | Rare but serious | Much rarer |
| Duration of action | Variable, may need twice-daily dosing | Half-life about 24 hours, once-daily dosing |
| Effect on insulin sensitivity | Generally neutral | Improves insulin sensitivity |
| Main route of elimination | Often significant kidney excretion | Mainly liver/biliary; minimal kidney excretion |
Telmisartan is metabolised in the liver by glucuronidation and is excreted almost entirely through bile into the faeces. Less than 1% of the drug is eliminated unchanged in the urine. This is important: patients with reduced kidney function or those on dialysis are less likely to accumulate the drug. The long half-life of about 24 hours means telmisartan provides consistent blood pressure control through the day and night, including the early-morning surge when heart attacks and strokes are most common.
Telmisartan is not just a blood pressure pill. Large international trials have proven its cardiovascular benefits.
| Study | Population | Key Finding |
|---|---|---|
| ONTARGET | 25,620 people with high cardiovascular risk | Telmisartan was as effective as ramipril in reducing cardiovascular death, heart attack, stroke and heart failure, but with fewer coughs and better tolerability. |
| TRANSCEND | People who could not tolerate ACE inhibitors | Telmisartan reduced cardiovascular events compared with placebo, offering a safe alternative for ACE-intolerant patients. |
| PRoFESS | Recent stroke patients | Confirmed blood pressure lowering and secondary prevention role. |
Many Australians over 30 struggle with weight gain, prediabetes or type 2 diabetes. Telmisartan is unique among ARBs: it partially activates PPAR-gamma, a receptor involved in glucose and fat metabolism. Studies show telmisartan improves insulin sensitivity, lowers fasting insulin levels, and may reduce the risk of new-onset diabetes. This makes it an excellent choice if you have high blood pressure plus metabolic syndrome, prediabetes, or a family history of type 2 diabetes.
Many patients try to lower blood pressure by using salt substitutes. In Australia, these products often replace sodium chloride with potassium chloride. While reducing sodium is good, the extra potassium can be dangerous when combined with telmisartan or other blood pressure medicines that affect potassium balance. Excess potassium can cause irregular heart rhythms and cardiac arrest. Important: If you take telmisartan, avoid potassium-based salt substitutes unless your doctor has checked your potassium levels and given approval. Use herbs, garlic, lemon juice, pepper and spices to flavour food instead.
Patients on dialysis still need blood pressure control and heart protection. Telmisartan is highly protein-bound and is not significantly removed by haemodialysis. It can be used in dialysis patients, but doctors usually start with a low dose of 20 mg once daily and monitor blood pressure and potassium carefully. Because it is minimally excreted by the kidneys, drug accumulation is less of a concern than with many other blood pressure medications.
Because telmisartan is cleared mainly by the liver, dose adjustment is necessary in liver disease. In mild to moderate hepatic impairment, the maximum recommended dose is 40 mg once daily. Telmisartan should not be used in severe liver disease or biliary obstruction. Always tell your doctor about any history of liver problems.
In Australia, telmisartan is available through the Pharmaceutical Benefits Scheme (PBS). It is prescribed under streamlined authority for hypertension. This means your GP can prescribe it easily without complex paperwork when you meet the PBS criteria—commonly when an ACE inhibitor has caused cough or intolerance. This makes telmisartan affordable and accessible for most Australians. It is also available on private prescription if required.
| Clinical Situation | Dosing Advice |
|---|---|
| Standard starting dose | 40 mg once daily, may increase to 80 mg once daily |
| ACE inhibitor cough | Switch to telmisartan 40 mg once daily after stopping ACE inhibitor |
| Mild–moderate liver disease | Maximum 40 mg once daily |
| Severe liver disease / biliary obstruction | Do not use |
| Dialysis patients | Start 20 mg once daily, monitor potassium |
| Using potassium salt substitutes | Avoid them; monitor serum potassium |
Telmisartan offers 24-hour blood pressure control, proven heart and brain protection, a low risk of cough, kidney-friendly metabolism, and a unique metabolic benefit for insulin sensitivity. If you are over 30 and living with high blood pressure, or if your current blood pressure medicine causes a cough, it may be time to talk to your GP about telmisartan.
Your next steps:
Don’t let a cough or outdated medication stop you from protecting your heart and brain. Telmisartan could be the change that makes your blood pressure treatment finally easy to live with.
This article is for general educational information and is not a substitute for individual medical advice. Always consult your GP or specialist before starting, changing or stopping any medication.